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The limited success of immunotherapy in solid tumors arises from several key challenges: The immunosuppressive and hypoxic TME impairs T cell proliferation, differentiation, and effector functions

A., & Magdich, L

99 The common adverse effects of SSZ include gastrointestinal and central nervous system toxicity, rash, liver function abnormalities, leukopenia and agranulocytosis, megaloblastic anemia, oligospermia, and infertility

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Decreased glutathione levels can lead to increased oxidative stress, impaired detoxification, compromised immune function, and potentially chronic pain